Table of Contents
Hormone Replacement Therapy
Major Premarin Trial Halted
One of the largest and best-designed federal studies of hormone replacement therapy was halted because women taking the hormones after menopause had a greater risk of:
Breast Cancer, Heart Attack, Stroke and Blood Clots
than those who did not take the drugs. The trial, which was to last for 8.5 years, was halted to continue till 2005 because of a significant increase in the risk of invasive breast cancer.
More than 6 million women in the US currently take estrogen and progestin (Prempro) combination therapy for a variety of reasons, including relief of hot flashes and other menopausal symptoms.
This has significant implications, however Premarin was introduced in 1942. It was the most-prescribed drug in America each year from 1992 through 1999 and perhaps the most prescribed drug ever.
Last year Premarin generated more than $2 billion in sales for Wyeth.
Please recognize that the progestin drug used in this study is not the same as human progesterone, but a synthetic derivative of the natural female hormone progesterone. Progestin can actually kill a fetus if taken when the woman is pregnant. The only reason it is used is the drug companies have a patent on it and can make more money than the safer natural progesterone.
The confusion about estrogen is that it actually raises levels of HDL (or "good") cholesterol in women, which is often considered one of the reasons that a woman’s risk of heart disease is low prior to menopause. For years, HRT was widely believed to reduce the risk of heart disease in postmenopausal women, but recent studies have failed to document any protective effects.
The hope-and the hype of the drug companies-has been that estrogen would also confer a reduced risk of heart disease. The study suggests the exact opposite though, in that when women take the drugs for more than about 5 years, the risks of the hormones clearly outweigh the benefits.
The trial involved over 16,000 women aged 50 to 79 who still had their uterus. Such women are given a combination of estrogen and progestin, because estrogen alone can promote cancer in the lining of the uterus. The new findings do not apply to the health effects of estrogen alone, which is being looked at in a separate study by researchers at the NHBI.
The findings support the recent American Heart Association recommendations that postmenopausal women should not take hormone therapy to lower their risk for heart disease.
Interestingly this study comes right on the heels of another full test article that was published the week earlier in JAMA, which showed the similar negative findings regarding estrogen and heart disease.
The original Heart and Estrogen/Progestin Replacement Study (HERS) study found that women taking hormone therapy were up to three times more likely to develop blood clots than those taking a placebo.
Hormone therapy was also associated with a higher risk of gallbladder disease surgery in the study. Together, the findings argue that hormone replacement therapy should not be recommended for postmenopausal women with heart disease.
JAMA July 17, 2002;288:321-333
Dr. Maloof’s Comments
Dr. Maloof has helped thousands of women balance their hormones through her specific treatments and using natural nutritional supplements. Many women have come in with PMS problems, bad cramps, mood swings, bloating, depression, heavy bleeding, menopausal sypmtoms including weight gain, irritablity and hot flashes.
Through Dr. Maloof’s techniques and treatment she uses along with natural supplementation she has achieved great success. Just read a her patient testimonials.
Female Patient age 19:
Every month I would miss 2 days of school every time I got my period, taking heavy doses of pain medication. Sometimes I would even go to the emergency room, the pain was so severe. They even put me on the birth control pill to try to help with the pain and it didn’t work!! After seeing Dr. Maloof and getting her adjustments and taking natural supplements I now breeze through my period every month pain-free.
Female Patient age 49:
I was having severe hot flashes that were unbearable. I had been to all the doctors and I was taking a large amount of prescription medication including hormone replacement therapy. Even with all the medications my hot flashes did not get any better. I went to see Dr. Maloof and she examined me and found out that I had hormonal imbalances, as well as nerve interference relating to my female organs which was affecting my hormones. With Dr. Maloof’s adjustments and nutritional supplements I have no more hot flashes!!!! The best part is I feel healthier, have more energy and I don’t need to take hormone replacement therapy.
Quotes of the Week
"Being healthy is not a short term program, it is a way of life." Dr. Catherine Maloof
"Health comes from above, down inside out." Dr. Catherine Maloof
"The simple truth is that happy people generally don’t get sick." Bernie S. Siegel, MD
"I value the friend who for me finds time on his calendar, but I cherish the friend who for me does not consult his calendar." Robert Brault
Dr. Catherine Maloof
Dr. Maloof Online,ã 2002
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